advised that this publication is issued solely for informational purposes and should not be construed as an 2020 is not over yet, of course, and the takeouts of Immunomedics and Myokardia show that buyers are prepared to pay big bucks, and big premiums, when they have to. With multiple partnerships in place and a regulatory filing on the near-term horizon, the stock should roar back to life in 2022. If some of the drugmaker's other high-value pipeline candidates pan out, a $32 billion-plus price tag wouldn't be all that unreasonable. Merck's first attempt was in late January 2020, when the pharma offered Pandion $65 million upfront to acquire the biotech's research, including its most advanced drug candidate at the time, PT-101. It is also being tested as a treatment for rheumatoid arthritis, spinal cord injury spasticity, and post-traumatic stress disorder. Opiant Pharmaceuticals, Inc. ( NASDAQ: OPNT) is a nano-cap pharma that's being acquired by small-cap pharma Indivior PLC ( OTCPK:INVVY ). There's a special meeting of stockholders on March 1, and I'd expect the deal to close out soon after, provided HSR runs out without any issues. List of largest pharmaceutical mergers and acquisitions, GlaxoSmithKlineNovartis Consumer Healthcare, "FirstWord Lists The 20 largest pharma M&A deals", Bristol-Myers set $2.2 billion termination fee for their mega deal, "Allergan Accelerates Transformation to Branded Growth Pharma Leader by Divesting Global Generics Business to Teva for $40.5 Billion", "Teva CEO: $40.5 Billion Allergan Deal is Just the Beginning", "Teva Snaps Up Allergan's Generics Arm, Dumping Mylan", "Pfizer And Allergan Merger Ranks As Biggest-Ever Pharmaceutical Deal", "Japan's Takeda clinches 45.3 billion Shire deal as pharma M&A rolls on", "FirstWord Lists The 20 largest pharma M&Adeals", "Pfizer Ends $160B Acquisition of Allergan after U.S. Compliance. your financial adviser and does not provide any individualized investment advice to you. Alnylam Pharmaceuticals (ALNY -0.81%) is a ribonucleic acid interference, or RNAi, drug development specialist. Sign up for free today. Cliccando su Accetta tutto accetti che Yahoo e i suoi partner possano trattare i tuoi dati personali e utilizzare tecnologie come i cookie per mostrarti annunci e contenuti personalizzati, per la misurazione degli annunci e dei contenuti, per l'analisi del pubblico e per lo sviluppo dei prodotti. Learn More. Already this month, weve seen two multi-billion-dollar pharma buyouts. The drug, approved by the U.S. Food and Drug Administration (FDA) in November 2018, is starting to look like a blockbuster therapy. That's if we simplify the situation to assume the merger closes. Pour en savoir plus sur notre utilisation de vos informations, veuillez consulter notre Politique relative la vie prive et notre Politique en matire de cookies. Jazz bought the Xyrem brand back in 2005 when it bought Orphan Medical. Thats just sad. Here are four reasons why the deal makes sense, at least for Jazz: GW Pharmaceuticals is the biggest player in pharmaceutical uses of cannabis, with a market cap of $3.9 billion, making it the sixth-largest marijuana-related stock in the world. And its also planning to expand into oncology products. The company has remained resilient during the M&A boom in pharma, refraining from making recklessacquisitions. Johnson & Johnson announced that it was acquiring Guidant on December 15, 2004, for $76 a share, with the deal being approved later approved on April 27, 2005 by Guidant shareholders. Biotech Stocks To Watch And Pharma Industry News, Leading Health Stock With Rising Earnings Estimates Nears Buy Point, Novartis ADR Meets 80-Plus Relative Strength Rating Benchmark, Stock Upgrades: Novartis ADR Shows Rising Relative Strength, HALO Stock: Halozyme Gets Under Your Skin To Deliver Blockbuster Drugs And Booming Growth, Biopharma Bristol-Myers Unfazed By Generic Competition For Cancer Cash Cow, Bristol Myers Relies On 'Mature' Products For Narrow Quarterly Beat, Novartis Offers Mixed Earnings Report As It Approaches A Key Spinoff. Data is a real-time snapshot *Data is delayed at least 15 minutes. As the company investigates therapy possibilities for the drug, that number is likely to take off. On Friday, AUPH stock tumbled below its 50-day moving average, according to MarketSmith.com. Realtime quote and/or trade prices are not sourced from all markets. Is this happening to you frequently? However, Jazz's stock immediately took a small hit with the announcement, as is typical when one company buys another. Meanwhile, Teva Pharmaceutical Industries (NYSE: TEVA), a drug maker with a $55 billion market cap, has noted that its actively looking for deals in the $10 billion to $15 billion range. Their prospects for a buyout are strong, but look for both to continue innovating whether a suitor comes or not. Almost all of Indivior's assets are focused on treating addiction. The following table lists the largest mergers and acquisitions in the pharmaceutical and biotechnology industry (those over $10 billion). Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. The Motley Fool has positions in and recommends Alnylam Pharmaceuticals, Axsome Therapeutics, Merck & Co., and Seagen Inc. Opiant pharmaceutical (Opiant presentation). Next is Jazz, which has one of the most effective narcolepsy treatments in the market, Xyrem. Indivior specializes in drugs that treat addiction. The bottom line is that Karuna is unlikely to remain independent leading into KarXT's upcoming regulatory filing in mid-2023. Opiant Pharmaceuticals, Inc. ( NASDAQ: OPNT) is a nano-cap pharma that's being acquired by small-cap pharma Indivior PLC ( OTCPK:INVVY ). In brief, Alnylam's RNAi platform ought to generate multiple blockbuster products in the years to come. Join us for the Virtual Trading Summit and learn the fundamentals of smart investing! This was eventually thwarted by. Tepezza had generated nearly $1.5 billion in the nine months ended Sept. 30, a growth of 37% from last year, while Krystexxa garnered $500 million, up 27% from the prior year. Axsome is also developing a late-stage migraine candidate called AXS-07, along with a fibromyalgia candidate called AXS-14. In early February, Merck proposed a buyout at a price of $40 per share, which it revised two days later to $50 per share. My roots are in the value school but over time I've learned to respect different approaches. Those reports pushed AUPH stock to a record high. I have no business relationship with any company whose stock is mentioned in this article. Especially with OTC use, it will be a much better experience if a one-shot dose will do the job. A Division of NBCUniversal. Hikma Pharmaceuticals PLC closed 4.32 short of its 52-week high (21.37), which the company reached on March 25. George Budwell has positions in Axsome Therapeutics. Opiant Pharmaceuticals trades barely above the threshold for HSR, so it would be pretty annoying if they got a 2nd request. Two names jump out to me; both are in the sweet spot of pharma buyouts, trading with market caps between $10 billion and $15 billion. Valeant raised its unsolicited offer for Allergan Inc. to $49.4 billion, adding more cash to the bid in an effort to win backing from Allergan and its investors, with the value of each share rising to $166.16 per Allergan share. Why Alnylam Pharmaceuticals Stock Is Vaulting Higher Today. I am not receiving compensation for it (other than from Seeking Alpha). The CVR helps to bridge the gap between the price the seller wants and the buyer wants to pay. It's not likely to go any higher than that $7. The company has gone from making a Monsanto and Syngenta held preliminary talks with both sets of advisers in the preceding few months, with talks centered on a combination. I've allocated a ~3.8% of the net asset value of my portfolio here. 2023 CNBC LLC. Clovis Oncology is an American pharmaceutical company specialized in oncology treatments. Shares of Aurinia hit a record high in November, but have since fallen on the lack of takeover news. Meanwhile, many large drug developers are in need of pipeline infusions. In closing, the two pharma stocks above are intriguing for different reasons. Get market updates, educational videos, webinars, and stock analysis. Opiant's primary asset is OPNT003 and Indivior probably wanted to take it out before the PDUFA date. Deal value ($bn) GW is beginning two phase 3 clinical trials in the U.S. of another cannabis-related drug, Sativex (known as Nabiximols outside the U.S.). The Motley Fool has no position in any of the stocks mentioned. I'd never go all-in on something like this, but to further diversify my portfolio, it is hard to pass it up entirely. Six times BIGGER Dividends with this one stock. Here's the Stock to Buy Now, Join Nearly 1 Million Premium Members And Get More In-Depth Stock Guidance and Research, Copyright, Trademark and Patent Information. I'm not worried about whether they have the money. Rather, it is choosing to wait for the right opportunity. So why the sudden interest in buying up smaller pharma companies? Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. of your investment. Tim Walbert, Chairman, President and CEO of Horizon Therapeutics attends the Horizon Irish Open announcement at The K Club on April 25, 2022 in Straffan, Ireland. It has also estimated more than $1.5 billion in peak U.S. annual sales of its second largest drug Krystexxa, used for the treatment of gout that is not controlled by other medicines. Readers are Not so for Synthorx and Spark, the takeovers of which were presumably competitive processes. In my opinion, it is credible that the roll-out of an approved OPNT003 would happen much faster after this merger. Transactions are recorded by the highest All Rights Reserved. We look forward to working with Opiant's talented team as we undertake our shared mission of changing patients' lives through access to life-transforming treatment for substance use disorders.". It is supposed to work better and/or be easier to administer than what's in the market right now, and unfortunately, it appears this is still a growing market. ET, 3 Top Marijuana Stocks to Buy for the Long Haul, This Exciting Growth Sector Is Predicted to Keep Doubling Until 2028, Why Jazz Pharmaceuticals Stock Rose 13.3% in March, Social Security: 4 Big Changes Washington Wants to Make, Warren Buffett Is Raking in $4.84 Billion in Annual Dividend Income From These 6 Stocks, 3 High-Growth Stocks That Could Be Worth $1 Trillion in 10 Years -- or Sooner, History Suggests the S&P 500 Could Soar in 2023. The product portfolios overlap because they serve a similar patient population, but they're fundamentally different in how or when they're used. Bayer advanced talks with Monsanto's management and subsequently raised its off by $3 billion, to more than $65 billion - which represented a 2 percent increase on its previous offer. Boosting this years average are takeovers from Nestle and Alexion, of Aimmune and Portola respectively, deals that rank among the five richest across all the years in this analysis. Note that there is always a chance (however slight) that the deal won't close, and then you are looking at 60% downside or more. Regulatory filing in mid-2023 one-shot dose will do the job Fool member today to get instant access our! Many large drug developers are in need of pipeline infusions one-shot dose do... Also being tested as a treatment for rheumatoid arthritis, spinal cord injury spasticity, and more -0.81. The value school but over time i 've allocated a ~3.8 % of the net asset value of my here! 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